An awkward teenage girl named Irene transfers to Saint Mary's Boarding School in the middle of the school year. A clique of popular girls at the school led by a girl named Madison immediately conspire to harass and bully Irene. While working on her school science fair project, Irene becomes convinced that Madison has psychic abilities and sets out to convince her. Eventually it appears that Madison does have several powers, including some ability to read minds, and to materialize needed objects which then disintegrate after they have served their purpose. As Madison becomes more confident in her psychic powers, she and Irene become closer. Irene, Madison and her friends end up on the roof, drinking and smoking marijuana where Irene loses her footing and falls three stories, hitting the ground. When Madison runs to her, it appears Irene is dead but she then wakes up and believes Madison has saved her. Madison's old friends then befriend Irene while Madison distances herself from all of them. Events escalate at the school science fair where Madison's old friends have set up a project called "Anatomy of a Loser" with several displays bizarre looping video and glitching, distorted images of Irene. Irene recoils in horror and lets out a primal scream, causing the displays to break and Madison's old friends all drop dead on the spot. Madison confronts Irene, accusing her of having psychic powers, and of using them to control her and kill the other girls, all of which Irene denies. Madison admits when Irene walked in their classroom the first time, she just wanted her to be normal so she could have a real friend but then her odd behavior caused her to lash out. Irene convinces Madison that she actually cares for her and isn't using her just to be popular. Madison embraces Irene, recognizing her as a friend, causing Irene's body to disintegrate into ashes now that Madison's desire to find a friend is fulfilled. Sometime later, a new girl enrolls at Saint Mary's as Madison plans to befriend her.